A Daily Glass of Orange Juice May Reduce Inflammation and Support Heart Health, New 2025 Study Finds
A new 2025 study is reshaping what we know about orange juice. Scientists say a daily glass of pure orange juice may do far more than boost energy — it may help lower inflammation, improve blood pressure regulation, and support long-term heart health.
A Simple Drink With a Big Impact
Researchers asked adults to drink 500 ml of pasteurised orange juice every day for 60 days. The results surprised them: thousands of genes inside immune cells changed their activity.
Several key inflammation-related genes — NAMPT, IL6, IL1B, NLRP3 — became less active. Another gene, SGK1, which influences sodium retention and blood pressure, also quieted down. These changes align with earlier studies showing orange juice can gently reduce blood pressure in young adults.
Why Orange Juice Works
Experts point to hesperidin, a natural citrus flavonoid with antioxidant and anti-inflammatory properties. It supports:
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Blood vessel relaxation
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Cholesterol balance
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Healthier sugar metabolism
This may explain why orange juice has shown consistent heart-health benefits across studies.
Metabolism, Weight, and Gut Health
The response isn’t the same for everyone.
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Overweight participants showed larger changes in fat-metabolism genes.
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Lean participants experienced stronger reductions in inflammation genes.
Other research adds to the picture. In 639 people across 15 trials, orange juice lowered insulin resistance and LDL cholesterol. Studies also show it may:
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Improve endothelial function
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Support healthy gut bacteria
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Reduce inflammatory markers
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Improve blood flow
Even small improvements in these areas can add up over years.
More Than a Breakfast Drink
Orange juice is part of daily routines and cultural traditions around the world — and now science suggests it may also serve as a functional food offering measurable cardiovascular benefits.
Researchers emphasize that whole fruit is still the best option due to fibre, but a modest daily serving of pure orange juice appears to support:
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Lower inflammation
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Better blood pressure control
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Improved metabolic health
A simple, familiar drink may be more powerful than we ever imagined.
references:
https://theconversation.com/your-daily-orange-juice-could-be-helping-your-heart-270492
